공성호 교수는 위암, 양성 위장관질환, 비만대사수술 등의 주제에 대해 발생기전, 진단, 치료의 전 분야에서 다양한 스펙트럼의 임상연구와 중개연구를 주도하고 참여하여 2022년 현재까지 약 160여편의 논문을 출판하였습니다.

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연구과제 수행이력 (지원기관)

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• 근적외선 형광 내시경검사 및 영상유도 수술에의 활용을 위한 c-KIT 양성 위장관기질종양 표적 면역 프로브 개발 ((재)한국연구재단)

• 위주변 림프절 구역의 인도시아닌그린 형광 네비게이션을 이용한 환자 맞춤형 위암수술의 실현가능성을 평가하는 전향적 코호트 연구 (한국스트라이커(주))

• 위암 환자의 복강경 위절제술에서 에너지 기반 절단기구 간의 비교 연구 (메트트로닉 ㈜)

• 자유로운 위치 전개가 가능한 동작용 보조로봇과 집도의의 수술을 보조하는 조종용 보조로봇으로 구성된 복강경 수술 협동형 보조로봇 시스템의 개발 (한국산업기술평가관리원)

• 복강경 solo surgery를 위한 인공지능 기반 수술 보조 로봇 시스템 개발 ((재)한국연구재단)

• 위암 복강경 내시경 시뮬레이션 모델 및 맞춤형 위암 수술을 위한 계측 소프트웨어 개발 (서울대학교병원)

• 소화기암 관련 호기가스의 고감도 및 선택적 검출을 위한 원천기술 개발 (한국산업기술평가관리원)

• 위 악성 종양 환자에서 특정 분자 마커에 대한 특이적 근적외선 형광 표지자를 사용한 맞춤형 비침습적 진단 및 치료의 개발 (서울대학교병원)

• 위절제술에서 수술중 신경생리검사를 통한 복강내 미주신경의 기능 및 보존율 평가 (서울대학교병원)

• 전자회로위에 위점막 세포를 배양하여 위장질환을 재현하고 약물 반응을 평가하기 위한 스토막온어칩 (Stomach-on-a chip)의 개발 (서울대학교병원)

• Liposome(M-ResQ)기반 면역항암제의 위암모델에서의 효능평가 ((주)단디바이오사이언스)

• RNA 성숙과정을 통해 위암 진행을 촉진하는 Dead-box helicase (DDX) 유전자에 대한 연구 ((재)한국연구재단)

• 유문보존위절제술 직후 위배출 향상에 대한 수술 중 Prabotulinum toxin A (나보타® 주)투여로 인한 일시적 유문 확장의 효용성과 안전성: 다기관 전향적 무작위배정 대조시험 (BIGEPPG trial) (㈜대웅제약)

• 위암 환자에서 구역별 림프절 전이율 예측 모델 개발 (서울대학교병원)

Publications about Medical Devices

Park JH, Berlth F, Wang C, Wang S, Choi JH, Park SH et al. Mapping of the perigastric lymphatic network using indocyanine green fluorescence imaging and tissue marking dye in clinically advanced gastric cancer. European Journal of Surgical Oncology. 2022 Feb;48(2):411-417. https://doi.org/10.1016/j.ejso.2021.08.029

Barberio M, Pizzicannella M, Spota A, Ashoka AH, Agnus V, Al Taher M et al. Preoperative endoscopic marking of the gastrointestinal tract using fluorescence imaging: submucosal indocyanine green tattooing versus a novel fluorescent over-the-scope clip in a survival experimental study. Surgical Endoscopy. 2021 Sep;35(9):5115-5123. https://doi.org/10.1007/s00464-020-07999-2

Jeong K, Kong SH, Bae SW, Park CR, Berlth F, Shin JH et al. Evaluation of near-infrared fluorescence-conjugated peptides for visualization of human epidermal receptor 2-overexpressed gastric cancer. Journal of Gastric Cancer. 2021 Jun;21(2):191-202. https://doi.org/10.5230/jgc.2021.21.e18

Park SH, Lee HJ, Park JH, Kim TH, Son YG, Huh YJ et al. Clinical Significance of Intra-operative Gastroscopy for Tumor Localization in Totally Laparoscopic Partial Gastrectomy. Journal of Gastrointestinal Surgery. 2021 May;25(5):1134-1146. https://doi.org/10.1007/s11605-020-04809-x

Marchegiani F, Noll E, Riva P, Kong SH, Saccomandi P, Vita G et al. Effects of Warmed and Humidified CO2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis. Surgical Innovation. 2021 Feb;28(1):7-17. https://doi.org/10.1177/1553350620967225

Legner A, Kong SH, Liu YY, Shabat G, Halvax P, Saadi A et al. The GAMMA concept (gastrointestinal activity manipulation to modulate appetite) preliminary proofs of the concept of local vibrational gastric mechanical stimulation. Surgical Endoscopy. 2020 Dec 1;34(12):5346-5353. https://doi.org/10.1007/s00464-019-07325-5

Ashoka AH, Kong SH, Seeliger B, Andreiuk B, Soares RV, Barberio M et al. Near-infrared fluorescent coatings of medical devices for image-guided surgery. Biomaterials. 2020 Dec;261. 120306. https://doi.org/10.1016/j.biomaterials.2020.120306

Park SH, Berlth F, Choi JH, Park JH, Suh YS, Kong SH et al. Near-infrared fluorescence-guided surgery using indocyanine green facilitates secure infrapyloric lymph node dissection during laparoscopic distal gastrectomy. Surgery Today. 2020 Oct 1;50(10):1187-1196. https://doi.org/10.1007/s00595-020-01993-w

Park SJ, Lee EJ, Kim SI, Kong SH, Jeong CW, Kim HS. Clinical desire for an artificial intelligence-based surgical assistant system: Electronic survey-based study. JMIR Medical Informatics. 2020 May;8(5). e17647. https://doi.org/10.2196/17647

Park SH, Suh YS, Park JH, Kim TH, Son YG, Huh YJ et al. Near-infrared image-guided laparoscopic omental flap for breast cancer. Asian journal of endoscopic surgery. 2020 Apr 1;13(2):250-255. https://doi.org/10.1111/ases.12709

Pop R, Kong SH, Langlois A, Marchegiani F, Shlomovitz E, Legnèr A et al. Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization. Surgical Innovation. 2019 Jun 1;26(3):280-292. https://doi.org/10.1177/1553350619838098

Huh YJ, Lee HJ, Kim TH, Choi YS, Park JH, Son YG et al. Efficacy of Assessing Intraoperative Bowel Perfusion with Near-Infrared Camera in Laparoscopic Gastric Cancer Surgery. Journal of Laparoendoscopic and Advanced Surgical Techniques. 2019 Apr 1;29(4):476-483. https://doi.org/10.1089/lap.2018.0263

Kong SH, Kim SM, Kim DG, Park KH, Suh YS, Kim TH et al. Intraoperative neurophysiologic testing of the perigastric vagus nerve branches to evaluate viability and signals along nerve pathways during gastrectomy. Journal of Gastric Cancer. 2019 Mar;19(1):49-61. https://doi.org/10.5230/jgc.2019.19.e2

Kong SH, Marchegiani F, Soares R, Liu YY, Suh YS, Lee HJ et al. Fluorescence lymphangiography-guided full-thickness oncologic gastric resection. Surgical Endoscopy. 2019 Feb 15;33(2):620-632. https://doi.org/10.1007/s00464-018-6402-y

Zhu C, Kong SH, Kim TH, Park SH, Ang RRG, Diana M et al. The anatomical configuration of the splenic artery influences suprapancreatic lymph node dissection in laparoscopic gastrectomy: analysis using a 3D volume rendering program. Surgical Endoscopy. 2018 Aug 1;32(8):3697-3705. https://doi.org/10.1007/s00464-018-6201-5

Diana M, Noll E, Legnèr A, Kong SH, Liu YY, Schiraldi L et al. Impact of valve-less vs. standard insufflation on pneumoperitoneum volume, inflammation, and peritoneal physiology in a laparoscopic sigmoid resection experimental model. Surgical Endoscopy. 2018 Jul 1;32(7):3215-3224. https://doi.org/10.1007/s00464-018-6039-x

Kim TH, Kong SH, Park JH, Son YG, Huh YJ, Suh YS et al. Assessment of the completeness of lymph node dissection using near-infrared imaging with indocyanine green in laparoscopic gastrectomy for gastric cancer. Journal of Gastric Cancer. 2018 Jun;18(2):161-171. https://doi.org/10.5230/jgc.2018.18.e19

Liu YY, Liao CH, Diana M, Wang SY, Kong SH, Yeh CN et al. Near-infrared cholecystocholangiography with direct intragallbladder indocyanine green injection: preliminary clinical results. Surgical Endoscopy. 2018 Mar 1;32(3):1506-1514. https://doi.org/10.1007/s00464-017-5838-9

Kong SH, Kim TH, Huh YJ, Oh SY, Ahn HS, Park SY et al. A feasibility study and technical tips for the use of an articulating bipolar vessel sealer in da Vinci robot-assisted gastrectomy. Journal of Laparoendoscopic and Advanced Surgical Techniques. 2017 Nov;27(11):1172-1179. https://doi.org/10.1089/lap.2017.0093

Kong SH, Haouchine N, Soares R, Klymchenko A, Andreiuk B, Marques B et al. Robust augmented reality registration method for localization of solid organs’ tumors using CT-derived virtual biomechanical model and fluorescent fiducials. Surgical Endoscopy. 2017 Jul 1;31(7):2863-2871. https://doi.org/10.1007/s00464-016-5297-8

Paulus CJ, Haouchine N, Kong SH, Soares RV, Cazier D, Cotin S. Handling topological changes during elastic registration: Application to augmented reality in laparoscopic surgery. International Journal of Computer Assisted Radiology and Surgery. 2017 Mar 1;12(3):461-470. https://doi.org/10.1007/s11548-016-1502-4

Diana M, Liu YY, Pop R, Kong SH, Legnèr A, Beaujeux R et al. Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. Surgical Endoscopy. 2017 Mar 1;31(3):1451-1460. https://doi.org/10.1007/s00464-016-5136-y

Oh SY, Choi B, Lee KG, Choe HN, Lee HJ, Suh YS et al. Ultrasonically Activated Shears Reduce Blood Loss without Increasing Inflammatory Reactions in Open Distal Gastrectomy for Cancer: A Randomized Controlled Study. Annals of Surgical Oncology. 2017 Feb 1;24(2):494-501. https://doi.org/10.1245/s10434-016-5518-3

Han TS, Hur K, Choi B, Lee JY, Byeon SJ, Min J et al. Improvement of anti-cancer drug efficacy via thermosensitive hydrogel in peritoneal carcinomatosis in gastric cancer. Oncotarget. 2017;8(65):108848-108858. https://doi.org/10.18632/oncotarget.22312

Diana M, Robinet E, Liu YY, Legnèr A, Kong SH, Schiraldi L et al. Confocal Imaging and Tissue-Specific Fluorescent Probes for Real-Time In Vivo Immunohistochemistry. Proof of the Concept in a Gastric Lymph Node Metastasis Model. Annals of Surgical Oncology. 2016 Dec 1;23:567-573. https://doi.org/10.1245/s10434-015-4928-y

Soares RV, Molos M, Donepudi P, Kong SH, Swanstrom LL. Transgastric hybrid surgery for the flexible endoscopist: early experience with the TAGSS system. Gastrointestinal Endoscopy. 2016 Nov 1;84(5):852-853. https://doi.org/10.1016/j.gie.2016.05.033

Liu YY, Kong SH, Diana M, Lègner A, Wu CC, Kameyama N et al. Near-infrared cholecysto-cholangiography with indocyanine green may secure cholecystectomy in difficult clinical situations: proof of the concept in a porcine model. Surgical Endoscopy. 2016 Sep 1;30(9):4115-4123. https://doi.org/10.1007/s00464-015-4608-9

Sohn SY, Lee DR, Lee SK, Kim H, Suh YS, Kong SH et al. WiLD: Widening view angle for lesion detection with gastroscopic images. In 2016 IEEE International Conference on Communications, ICC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. 7511600. (2016 IEEE International Conference on Communications, ICC 2016). https://doi.org/10.1109/ICC.2016.7511600

Liu YY, Pop R, Diana M, Kong SH, Lègner A, Beaujeux R et al. Real-time fluorescence angiography by intra-arterial indocyanine green injection to identify obscure gastrointestinal bleeding territory: proof of concept in the porcine model. Surgical Endoscopy. 2016 May 1;30(5):2143-2150. https://doi.org/10.1007/s00464-015-4460-y

Kong SH, Diana M, Liu YY, Lee HJ, Legner A, Soares R et al. Novel method for hybrid endo-laparoscopic full-thickness gastric resection using laparoscopic transgastric suture passer device. Surgical Endoscopy. 2016 Apr 1;30(4):1683-1691. https://doi.org/10.1007/s00464-015-4375-7

Kong SH, Noh YW, Suh YS, Park HS, Lee HJ, Kang KW et al. Evaluation of the novel near-infrared fluorescence tracers pullulan polymer nanogel and indocyanine green/γ-glutamic acid complex for sentinel lymph node navigation surgery in large animal models. Gastric Cancer. 2015 Jan;18(1):55-64. https://doi.org/10.1007/s10120-014-0345-3

Noh YW, Kong SH, Choi DY, Park HS, Yang HK, Lee HJ et al. Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping. ACS Nano. 2012 Sep 25;6(9):7820-7831. https://doi.org/10.1021/nn301949y

Kong SH, Oh BM, Yoon H, Ahn HS, Lee HJ, Chung SG et al. Comparison of two- and three-dimensional camera systems in laparoscopic performance: A novel 3D system with one camera. Surgical Endoscopy. 2010 May;24(5):1131-1143. https://doi.org/10.1007/s00464-009-0740-8