CEO
Major Research
Professor Seong-Ho KONG has published about 160 papers as of 2022 by leading and participating in a wide spectrum of clinical research and translational research about the pathophysiology, diagnosis, and treatment of gastric cancer, benign gastrointestinal diseases, and bariatric/metabolic surgery.
History of Research Project Performance (Supported Institution)
-
Development of an immune probe targeting c-KIT-positive gastrointestinal stromal tumors for near-infrared fluorescence-guidance endoscopy and image-induced surgery (National Research Foundation of Korea)
-
A prospective cohort study evaluating the feasibility of patient-specific gastric cancer surgery using indocyanine green fluorescence navigation for the perigastric lymph node basins (Stryker Korea Co., Ltd.)
-
A randomized clinical trial comparing different energy-based devices in laparoscopic gastrectomy for gastric cancer patients (Medtronic Co., Ltd)
-
Development of a laparoscopic surgical cooperative assistance robot system consisting of a motion assistance robot capable of free position development and a control assistance robot to assist the surgeon's surgery (Korea Evaluation Institute of Industrial Technology)
-
Development of an artificial intelligence-based surgical assistance robot system for laparoscopic solo surgery (National Research Foundation of Korea)
-
Development of laparoscopic and endoscopic simulation models and measurement software for tailored gastric surgery using 3D printing technology and medical imaging software (Seoul National University Hospital)
-
Development of technology for highly sensitive and selective detection of VOC related to digestive cancer (Korea Evaluation Institute of Industrial Technology)
-
Development of tailored non-invasive diagnosis and treatment options using specific near-infrared molecules in patients with gastric malignant tumour (Seoul National University Hospital)
-
Evaluation of function and viability of intraabdominal vagus nerves by intraoperative neurophysiologic monitoring in gastrectomy (Seoul National University Hospital)
-
Development of human stomach-on-a-chip for gastric diseases simulation and drug screening (Seoul National University Hospital)
-
Evaluation of efficacy of Liposome (M-ResQ)-based immuno-anticancer drug in gastric cancer model (Dandi Bioscience Co., Ltd.)
-
A study on the Dead-box helicase (DDX) gene that promotes gastric cancer progression through RNA maturation process (National Research Foundation of Korea)
-
Efficacy and safety of temporary pyloric dilatation by intraoperative PraBotulinum toxin A Injection for the improvement of Gastric Emptying immediate after Pylorus Preserving Gastrectomy: Multicenter Prospective randomized controlled trial (BIGEPPG trial) (Daewoong Pharmaceutical Co., Ltd.)
-
Development of a prediction model for lymph node metastasis by region in gastric cancer patients (Seoul National University Hospital)
Publications about Medical Devices
Park JH, Berlth F, Wang C, Wang S, Choi JH, Park SH et al. Mapping of the perigastric lymphatic network using indocyanine green fluorescence imaging and tissue marking dye in clinically advanced gastric cancer. European Journal of Surgical Oncology. 2022 Feb;48(2):411-417. https://doi.org/10.1016/j.ejso.2021.08.029
Barberio M, Pizzicannella M, Spota A, Ashoka AH, Agnus V, Al Taher M et al. Preoperative endoscopic marking of the gastrointestinal tract using fluorescence imaging: submucosal indocyanine green tattooing versus a novel fluorescent over-the-scope clip in a survival experimental study. Surgical Endoscopy. 2021 Sep;35(9):5115-5123. https://doi.org/10.1007/s00464-020-07999-2
Jeong K, Kong SH, Bae SW, Park CR, Berlth F, Shin JH et al. Evaluation of near-infrared fluorescence-conjugated peptides for visualization of human epidermal receptor 2-overexpressed gastric cancer. Journal of Gastric Cancer. 2021 Jun;21(2):191-202. https://doi.org/10.5230/jgc.2021.21.e18
Park SH, Lee HJ, Park JH, Kim TH, Son YG, Huh YJ et al. Clinical Significance of Intra-operative Gastroscopy for Tumor Localization in Totally Laparoscopic Partial Gastrectomy. Journal of Gastrointestinal Surgery. 2021 May;25(5):1134-1146. https://doi.org/10.1007/s11605-020-04809-x
Marchegiani F, Noll E, Riva P, Kong SH, Saccomandi P, Vita G et al. Effects of Warmed and Humidified CO2 Surgical Site Insufflation in a Novel Experimental Model of Magnetic Compression Colonic Anastomosis. Surgical Innovation. 2021 Feb;28(1):7-17. https://doi.org/10.1177/1553350620967225
Legner A, Kong SH, Liu YY, Shabat G, Halvax P, Saadi A et al. The GAMMA concept (gastrointestinal activity manipulation to modulate appetite) preliminary proofs of the concept of local vibrational gastric mechanical stimulation. Surgical Endoscopy. 2020 Dec 1;34(12):5346-5353. https://doi.org/10.1007/s00464-019-07325-5
Ashoka AH, Kong SH, Seeliger B, Andreiuk B, Soares RV, Barberio M et al. Near-infrared fluorescent coatings of medical devices for image-guided surgery. Biomaterials. 2020 Dec;261. 120306. https://doi.org/10.1016/j.biomaterials.2020.120306
Park SH, Berlth F, Choi JH, Park JH, Suh YS, Kong SH et al. Near-infrared fluorescence-guided surgery using indocyanine green facilitates secure infrapyloric lymph node dissection during laparoscopic distal gastrectomy. Surgery Today. 2020 Oct 1;50(10):1187-1196. https://doi.org/10.1007/s00595-020-01993-w
Park SJ, Lee EJ, Kim SI, Kong SH, Jeong CW, Kim HS. Clinical desire for an artificial intelligence-based surgical assistant system: Electronic survey-based study. JMIR Medical Informatics. 2020 May;8(5). e17647. https://doi.org/10.2196/17647
Park SH, Suh YS, Park JH, Kim TH, Son YG, Huh YJ et al. Near-infrared image-guided laparoscopic omental flap for breast cancer. Asian journal of endoscopic surgery. 2020 Apr 1;13(2):250-255. https://doi.org/10.1111/ases.12709
Pop R, Kong SH, Langlois A, Marchegiani F, Shlomovitz E, Legnèr A et al. Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization. Surgical Innovation. 2019 Jun 1;26(3):280-292. https://doi.org/10.1177/1553350619838098
Huh YJ, Lee HJ, Kim TH, Choi YS, Park JH, Son YG et al. Efficacy of Assessing Intraoperative Bowel Perfusion with Near-Infrared Camera in Laparoscopic Gastric Cancer Surgery. Journal of Laparoendoscopic and Advanced Surgical Techniques. 2019 Apr 1;29(4):476-483. https://doi.org/10.1089/lap.2018.0263
Kong SH, Kim SM, Kim DG, Park KH, Suh YS, Kim TH et al. Intraoperative neurophysiologic testing of the perigastric vagus nerve branches to evaluate viability and signals along nerve pathways during gastrectomy. Journal of Gastric Cancer. 2019 Mar;19(1):49-61. https://doi.org/10.5230/jgc.2019.19.e2
Kong SH, Marchegiani F, Soares R, Liu YY, Suh YS, Lee HJ et al. Fluorescence lymphangiography-guided full-thickness oncologic gastric resection. Surgical Endoscopy. 2019 Feb 15;33(2):620-632. https://doi.org/10.1007/s00464-018-6402-y
Zhu C, Kong SH, Kim TH, Park SH, Ang RRG, Diana M et al. The anatomical configuration of the splenic artery influences suprapancreatic lymph node dissection in laparoscopic gastrectomy: analysis using a 3D volume rendering program. Surgical Endoscopy. 2018 Aug 1;32(8):3697-3705. https://doi.org/10.1007/s00464-018-6201-5
Diana M, Noll E, Legnèr A, Kong SH, Liu YY, Schiraldi L et al. Impact of valve-less vs. standard insufflation on pneumoperitoneum volume, inflammation, and peritoneal physiology in a laparoscopic sigmoid resection experimental model. Surgical Endoscopy. 2018 Jul 1;32(7):3215-3224. https://doi.org/10.1007/s00464-018-6039-x
Kim TH, Kong SH, Park JH, Son YG, Huh YJ, Suh YS et al. Assessment of the completeness of lymph node dissection using near-infrared imaging with indocyanine green in laparoscopic gastrectomy for gastric cancer. Journal of Gastric Cancer. 2018 Jun;18(2):161-171. https://doi.org/10.5230/jgc.2018.18.e19
Liu YY, Liao CH, Diana M, Wang SY, Kong SH, Yeh CN et al. Near-infrared cholecystocholangiography with direct intragallbladder indocyanine green injection: preliminary clinical results. Surgical Endoscopy. 2018 Mar 1;32(3):1506-1514. https://doi.org/10.1007/s00464-017-5838-9
Kong SH, Kim TH, Huh YJ, Oh SY, Ahn HS, Park SY et al. A feasibility study and technical tips for the use of an articulating bipolar vessel sealer in da Vinci robot-assisted gastrectomy. Journal of Laparoendoscopic and Advanced Surgical Techniques. 2017 Nov;27(11):1172-1179. https://doi.org/10.1089/lap.2017.0093
Kong SH, Haouchine N, Soares R, Klymchenko A, Andreiuk B, Marques B et al. Robust augmented reality registration method for localization of solid organs’ tumors using CT-derived virtual biomechanical model and fluorescent fiducials. Surgical Endoscopy. 2017 Jul 1;31(7):2863-2871. https://doi.org/10.1007/s00464-016-5297-8
Paulus CJ, Haouchine N, Kong SH, Soares RV, Cazier D, Cotin S. Handling topological changes during elastic registration: Application to augmented reality in laparoscopic surgery. International Journal of Computer Assisted Radiology and Surgery. 2017 Mar 1;12(3):461-470. https://doi.org/10.1007/s11548-016-1502-4
Diana M, Liu YY, Pop R, Kong SH, Legnèr A, Beaujeux R et al. Superselective intra-arterial hepatic injection of indocyanine green (ICG) for fluorescence image-guided segmental positive staining: experimental proof of the concept. Surgical Endoscopy. 2017 Mar 1;31(3):1451-1460. https://doi.org/10.1007/s00464-016-5136-y
Oh SY, Choi B, Lee KG, Choe HN, Lee HJ, Suh YS et al. Ultrasonically Activated Shears Reduce Blood Loss without Increasing Inflammatory Reactions in Open Distal Gastrectomy for Cancer: A Randomized Controlled Study. Annals of Surgical Oncology. 2017 Feb 1;24(2):494-501. https://doi.org/10.1245/s10434-016-5518-3
Han TS, Hur K, Choi B, Lee JY, Byeon SJ, Min J et al. Improvement of anti-cancer drug efficacy via thermosensitive hydrogel in peritoneal carcinomatosis in gastric cancer. Oncotarget. 2017;8(65):108848-108858. https://doi.org/10.18632/oncotarget.22312
Diana M, Robinet E, Liu YY, Legnèr A, Kong SH, Schiraldi L et al. Confocal Imaging and Tissue-Specific Fluorescent Probes for Real-Time In Vivo Immunohistochemistry. Proof of the Concept in a Gastric Lymph Node Metastasis Model. Annals of Surgical Oncology. 2016 Dec 1;23:567-573. https://doi.org/10.1245/s10434-015-4928-y
Soares RV, Molos M, Donepudi P, Kong SH, Swanstrom LL. Transgastric hybrid surgery for the flexible endoscopist: early experience with the TAGSS system. Gastrointestinal Endoscopy. 2016 Nov 1;84(5):852-853. https://doi.org/10.1016/j.gie.2016.05.033
Liu YY, Kong SH, Diana M, Lègner A, Wu CC, Kameyama N et al. Near-infrared cholecysto-cholangiography with indocyanine green may secure cholecystectomy in difficult clinical situations: proof of the concept in a porcine model. Surgical Endoscopy. 2016 Sep 1;30(9):4115-4123. https://doi.org/10.1007/s00464-015-4608-9
Sohn SY, Lee DR, Lee SK, Kim H, Suh YS, Kong SH et al. WiLD: Widening view angle for lesion detection with gastroscopic images. In 2016 IEEE International Conference on Communications, ICC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. 7511600. (2016 IEEE International Conference on Communications, ICC 2016). https://doi.org/10.1109/ICC.2016.7511600
Liu YY, Pop R, Diana M, Kong SH, Lègner A, Beaujeux R et al. Real-time fluorescence angiography by intra-arterial indocyanine green injection to identify obscure gastrointestinal bleeding territory: proof of concept in the porcine model. Surgical Endoscopy. 2016 May 1;30(5):2143-2150. https://doi.org/10.1007/s00464-015-4460-y
Kong SH, Diana M, Liu YY, Lee HJ, Legner A, Soares R et al. Novel method for hybrid endo-laparoscopic full-thickness gastric resection using laparoscopic transgastric suture passer device. Surgical Endoscopy. 2016 Apr 1;30(4):1683-1691. https://doi.org/10.1007/s00464-015-4375-7
Kong SH, Noh YW, Suh YS, Park HS, Lee HJ, Kang KW et al. Evaluation of the novel near-infrared fluorescence tracers pullulan polymer nanogel and indocyanine green/γ-glutamic acid complex for sentinel lymph node navigation surgery in large animal models. Gastric Cancer. 2015 Jan;18(1):55-64. https://doi.org/10.1007/s10120-014-0345-3
Noh YW, Kong SH, Choi DY, Park HS, Yang HK, Lee HJ et al. Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping. ACS Nano. 2012 Sep 25;6(9):7820-7831. https://doi.org/10.1021/nn301949y
Kong SH, Oh BM, Yoon H, Ahn HS, Lee HJ, Chung SG et al. Comparison of two- and three-dimensional camera systems in laparoscopic performance: A novel 3D system with one camera. Surgical Endoscopy. 2010 May;24(5):1131-1143. https://doi.org/10.1007/s00464-009-0740-8